SAMi (Sperm Analysis Machine Intelligence) was developed by Andrologists and Computer Scientists at the University of Nottingham, specifically to provide semen analysis and sperm performance data much more efficiently and reliably than current manual methods.
The recognition of a need for automation in semen analysis has grown over many years. Not only is there a need to move away from manual methods that lack accuracy and reproducibility but also a need to catch up with the other fields in laboratory medicine.
SAMi is the only CASA (Computer Assisted Semen Analysis) system to be validated for human use.
It provides a simple intuitive solution, allow editing of the captured sperm screen to ensure that a. only sperm are detected and b. missed sperm can be replaced which gives a more reliable sperm concentration and one which is in line with the haemocytometer (Tomlinson et al, 2010).
- Ideal for routine semen analysis, sperm preparation, toxicity testing and research
- Quantitative sperm motility based on sperm swimming speed
- Video clips (.avi) of untracked and tracked samples saved to PC and easily accessed or emailed
- Simple reporting database
- EQA scheme (voluntary) – useful to determine accuracy and reproducibility against other labs
- Sperm counts validated versus World Health Organisation methods – sperm counts measured in parallel with Hemocytometer and SAMi
SAMi CASA system is very affordable – our flexible pricing model is based on an annual fee which includes maintenance support and access to the SAMi EQA scheme
Further technical details at www.andrologyconsulting.com
Contact email@example.com for details regarding demonstration and pricing
Validation of semen analysis methods is a challenging area since there are no standards or calibration materials available for the determination of either sperm number or motility
- Sperm concentration based on the imaging of a minimum number of spermatozoa as defined by the user. SAMi concentration shows parity with the Haemocytometer (current "Gold Standard")
- Provides analysis of sperm motility, classifying sperm into 4 grades (according to the WHO, 1999 and 2021). Motility is based on real swimming speed as opposed to manual analysis which can never represent anymore than a ‘rough estimate’.
- Provide an analysis of the overall velocity of the motile fraction of the sperm sample. Velocity helps to assess not only how many sperm move forward but how fast they go.
Important publications in relation to CASA and quality in andrology:
- Tomlinson MJ and Naeem A (2018). Computer-aided sperm analysis (CASA) in the medical laboratory: CASA in diagnostic andrology and assisted conception. Reproduction, Fertility and Development 30(6) 850-859 https://doi.org/10.1071/RD17520
- Aljaser FS, Campbell BK, Almajed FS4 and Tomlinson MJ (2017). Efficacy of Ultra-Rapid Freezing by Direct Immersion into Liquid Nitrogen for Sperm Cryopreservation and Its Potential for Male Fertility Preservation. Int J Innov Res Med Sci (IJIRMS) 2, 10, 1401-1412.
- Tomlinson MJ, Comajuan E, Naeem A and Pooley K (2016). Standards in reporting cryopreserved donor sperm characteristics: Should they be reported post thaw or post wash? RBMonline, 33(1):111-113
- Tomlinson MJ (2016). Debate : Uncertainty of measurement and clinical value of semen analysis: Has standardisation through professional guidelines helped or hindered progress ? Andrology, 4, 763-770.
- Dearing C, Kilburn S and Lindsey K (2014). Validation of the sperm class analyser CASA system for sperm counting in a busy diagnostic semen analysis laboratory. Hum Fertil (Camb) 2014 Mar;17(1):37-44.doi: 10.3109/14647273.2013.865843. Epub 2013 Dec 20.
- Tomlinson MJ, Naeem A, Hopkisson JF and Campbell B (2012) . Brief Communication: Assessment and validation of non-spermicidal condoms as specimen collection sheaths for semen analysis and assisted conception. Hum Fertil 15, 140-143